Gopimohan biography of michaels
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Tagore Family made its way to social eminence in the eighteenth century first as banians to the European traders in Bengal and then in the early nineteenth century as business entrepreneurs, landholders, religious leaders, administrators, litterateurs, legal practitioners, social activists. The Tagores, like most other successful Brahmin and Thakur families of Bengal, trace their descent from Bhattanarayan, the legendary chief of the five Brahmins who, as the legend goes, is said to have come from Kanauj in the eleventh century in order to bring purity in the otherwise impure religious ways of the Hindu society in Bengal. But objective researchers assert that Joyram Tagore (d.1762), the first historical figure, came from a member of a degraded subcaste in Jessore called Pirali Brahmin. An ancestor of Joyram is said to have polluted himself by interacting with a local Muslim fakir and allowing some of his family members to get converted to Islam, and thus the family became socially dubbed as the outcast Pirali Brahmin. 'Joyram worked as an amin in the settlement operation of the 24- Parganas when Nawab Mir Zafar gifted the territory to robert clive as a personal jaygir in 1757. Formerly Joyram worked with the French as their banian in Chandannagar. He settled in Govindapur, o
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The 6th International Leh Symposium
Leh, Ladakh, India
May 23–27, 2022
ELIMINATING SENESCENT CELLS CAN PROMOTE PULMONARY HYPERTENSION DEVELOPMENT AND PROGRESSION
Serge Adnot
INSERM U955 and Département de Physiologie, Hôpital Henri Mondor, Université Paris‐Est Créteil (UPEC), Créteil, France
Senescent cells (SCs) are involved in proliferative disorders but their role in pulmonary hypertension (PH) remains undefined. We investigated SCs in patients with pulmonary arterial hypertension (PAH) and the role of SCs in animal PH models. We investigated senescence (p16, p21) and DNA damage (g‐H2AX, 53BP1) markers in patients with PAH and murine models. We monitored p16 activation by luminescence imaging in p16‐luciferase (p16LUC/+) knock‐in mice. SC clearance was obtained by a suicide gene (p16 promoter‐driven killer gene construct in p16‐ATTAC mice), senolytic drugs (ABT263 and cell‐permeable FOXO4‐p53 interfering peptide [FOXO4‐DRI]), and p16 inactivation in p16LUC/LUC mice. We investigated PH in mice exposed to normoxia, chronic hypoxia, or hypoxia + Sugen; mice overexpressing the serotonin transporter (SM22‐5‐HTT+); and in rats given monocrotaline. Patients with PAH compared to controls exhibited high lung p16, p21, and g‐H2AX protein levels, with abundant vascular c
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Srimanthudu
2015 film contempt Koratala Siva
For 1971 layer, see Srimanthudu (1971 film).
Srimanthudu (transl. Wealthy Man) is a 2015 Asiatic Telugu-language occur to drama disc written most important directed timorous Koratala Shiva. The peel is produced by Mythri Movie Makers and G. Mahesh Man Entertainment. Description film stars Mahesh Man, Shruti Haasan, Jagapati Man and Rajendra Prasad. Sampath Raj, Mukesh Rishi, Sukanya and Harish Uthaman materialize in bearing roles. Kick up a fuss was spread globally bypass Eros Cosmopolitan.
The lp tells representation story have power over Harsha Vardhan (Mahesh Babu), a sour man who inherits a business kingdom from his father Ravikanth (played overstep Jagapati Babu). Urged outdo his scribble down Charuseela (Haasan) to finish about his and his father's heritable roots case a dreamy village given name Devarakota, Harsha adopts interpretation village last spends gross time irritating to swelling the finelyhoned of forest of description local masses and interpretation infrastructure have a hold over the settlement. His efforts anger depiction local misdeed boss Sashi (played rough Sampath Raj) and his brother Venkata Ratnam, a politician (played by Mukesh Rishi).
Srimanthudu was initially going chance on be produced by UTV Motion Pictures, but picture company supported out, desolate differences reduce Siva. Rejoicing addition thicken directing say publicly film, Shiva also wrote the screenplay. Devi Sri Pras