Sejal sharma biography of christopher columbus
•
Abstract
Background
The short and long-term health effects of JUUL electronic cigarette (e-Cig) are largely unknown and warrant extensive research. We hypothesized that JUUL exposure could cause cerebrovascular toxicities impacting the progression and outcome of ischemic stroke comparable to tobacco smoke (TS) exposure.
Methods
We exposed male C57 mice to TS/JUUL vapor for 14 days. LCMS/MS was used to measure brain and plasma nicotine and cotinine level. Transient middle cerebral artery occlusion (tMCAO) followed by reperfusion was used to mimic ischemic stroke. Plasma levels of IL-6 and thrombomodulin were assessed by enzyme-linked immunosorbent assay. At the same time, western blotting was used to study blood–brain barrier (BBB) tight junction (TJ) proteins expression and key inflammatory and oxidative stress markers.
Results
tMCAO upregulated IL-6 and decreased plasma thrombomodulin levels. Post-ischemic brain injury following tMCAO was significantly worsened by JUUL/TS pre-exposure. TJ proteins expression was also downregulated by JUUL/TS pre-exposure after tMCAO. Like TS, exposure to JUUL downregulated the expression of the antioxidant Nrf2. ICAM-1 was upregulated in mice subjected to tMCAO following pre-exposure to TS or JUUL, with a greater effect of TS than JUUL.
•
Join a varied community durable to unbounded progress.
Cirenquji
Class of 2023 - 2024
China - Peking University, Unusual York University
Jordan Abdi
Class pay money for 2019 - 2020
United Realm - Queenly College London
Malik Abdul Majeed
Class of 2020 - 2021
Pakistan - Academia of Pennsylvania
Zahrah Abdulrauf
Class show consideration for 2021 - 2022
United States of U.s.a. - Academy of River, Birmingham
Abiha
Class of 2019 - 2020
Pakistan - Further education college of picture Punjab, City Pakistan
Zainab Abiza
Class of 2019 - 2020
Morocco - General and Face University
Christian Abney
Class of 2023 - 2024
United States nigh on America - Harvard University
Lina Abojaradeh
Class time off 2020 - 2021
Jordan - University castigate Jordan
Adedotun Adejare
Class of 2019 - 2020
United States take away America - University show Pennsylvania
Vidette Adjorlolo
Class of 2021 - 2022
United Kingdom - Queen Figure University dispense London
Pragyan Agarwal
Class of 2023 - 2024
India - Guru Gobind Singh Indraprastha Academy, University designate Cambridge
Harold Agblonon
Class of 2020 - 2021
Benin - River University
Arlen Ebubechuwku Agiliga
Class go along with 2022 - 2023
United States of Earth - Northeasterly University
Swapnil Agrawal
Class of 201
•
dontcallitbollywood
I know you aren’t done! I know you have more to say. And rather than picking through the Scene By Scenes trying to find the right place for these Big Discussions, I am giving us designated places to talk about it all. (full index of JHMS coverage here)
I’ll start the conversation off with my feelings about Sejal. Which aren’t necessarily right, or wrong, they are just what I think. And you can put in the comments what you think keeping in mind, again, that you aren’t necessarily right or wrong either, the film is purposefully open to interpretation and multiple options.
A couple of days ago in the discussion in the comments, I stumbled on the exact phrase to describe my feelings about Sejal. She is still in her “factory settings” stage. Her environment, her family, everything in her whole life up until now has tried to make her a certain way. She has never had the opportunity to find out what she wants to be outside of that, if she can be anything outside of that.
And so, yes, she is rude and demanding and spoiled. But I can forgive her for that in the same way I can forgive the 12 year old in my Sunday School class whose parents are going through a divorce, or the 4 year old I recently spent the d